GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7692995 | 1 | rs13144223 | chr4:17872707 | NCAPG | chr4:17812525-17846485:+ | 0.11 | 4.22 | 2.66E-5 | Height |
| BRCA | cis | rs1061377 | 1 | rs13144374 | chr4:39130479 | KLHL5 | chr4:39046659-39123828:+ | -0.14 | -4.45 | 9.49E-6 | Uric acid levels |
| BRCA | cis | rs7692995 | 1 | rs13144742 | chr4:17974181 | NCAPG | chr4:17812525-17846485:+ | 0.1 | 4.48 | 8.1E-6 | Height |
| BRCA | cis | rs11733284 | 1 | rs13146880 | chr4:48031499 | CNGA1 | chr4:47937996-48018610:- | 0.21 | 7.11 | 2.19E-12 | Renal underexcretion gout;Gout |
| BRCA | cis | rs1364989 | 1 | rs13148062 | chr4:55005973 | FIP1L1 | chr4:54243820-54326102:+ | -0.16 | -3.47 | 0.000551 | Lupus nephritis in systemic lupus erythematosus |
| BRCA | cis | rs1109501 | 1 | rs13148900 | chr4:71361114 | AMTN | chr4:71384298-71398459:+ | -0.25 | -7.24 | 8.74E-13 | Alcoholism (heaviness of drinking) |
| BRCA | cis | rs2242330 | 1 | rs13151390 | chr4:68422349 | STAP1 | chr4:68424446-68473053:+ | -0.18 | -5.91 | 4.62E-9 | Parkinson's disease |
| BRCA | cis | rs7692995 | 1 | rs13151431 | chr4:17959581 | NCAPG | chr4:17812525-17846485:+ | 0.09 | 4.18 | 3.1E-5 | Height |
| BRCA | cis | rs7692995 | 1 | rs13151620 | chr4:17991679 | NCAPG | chr4:17812525-17846485:+ | 0.12 | 4.69 | 3.06E-6 | Height |
| BRCA | cis | rs7692995 | 1 | rs13152352 | chr4:17976846 | NCAPG | chr4:17812525-17846485:+ | 0.1 | 4.42 | 1.08E-5 | Height |
| BRCA | cis | rs2036402 | 1 | rs13153099 | chr5:156436195 | TIMD4 | chr5:156346293-156390266:- | -0.16 | -4.16 | 3.39E-5 | Hypertriglyceridemia |
| BRCA | cis | rs7443270 | 1 | rs13167641 | chr5:41232291 | C7 | chr5:40909599-40983039:+ | -0.11 | -4.63 | 4.13E-6 | Response to fenofibrate (adiponectin levels) |
| BRCA | cis | rs4601530 | 1 | rs1316829 | chr1:25051225 | CLIC4 | chr1:25071760-25170815:+ | -0.09 | -3.66 | 0.000267 | Height |
| BRCA | cis | rs13168670 | 1 | rs13168670 | chr5:140146899 | HARS2 | chr5:140071018-140078889:+ | -0.13 | -3.56 | 0.000386 | Schizophrenia |
| BRCA | cis | rs13168670 | 1 | rs13168670 | chr5:140146899 | PCDHA10 | chr5:140235634-140391929:+ | -0.14 | -3.65 | 0.000272 | Schizophrenia |